Article
Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.
The Journal of clinical investigation - 1 Apr 1996
Rockman H A, Hamilton R A, Jones L R, Milano C A, Mao L, Lefkowitz R J
Abstract excerpt
To assess the effect of targeted myocardial beta-adrenergic receptor (AR) stimulation on relaxation and phospholamban regulation, we studied the physiological and biochemical alterations associated with overexpression of the human beta2-AR gene in transgenic mice. These mice have an approximately...
Topics
- Animals
- Calcium-Binding Proteins
- Calcium-Transporting ATPases
- Calsequestrin
- Hemodynamics
- Humans
- Mice
- Mice, Transgenic
- Myocardial Contraction
- Myocardium
- Phenotype
- Receptors, Adrenergic, beta-2
- Sarcoplasmic Reticulum