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Article

Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein.

The Journal of clinical investigation - 1 Apr 1996

Rockman H A, Hamilton R A, Jones L R, Milano C A, Mao L, Lefkowitz R J

Abstract excerpt

To assess the effect of targeted myocardial beta-adrenergic receptor (AR) stimulation on relaxation and phospholamban regulation, we studied the physiological and biochemical alterations associated with overexpression of the human beta2-AR gene in transgenic mice. These mice have an approximately 200-fold increase in beta-AR density and a 2-fold increase in basal adenylyl cyclase activity relative to negative...

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Identifiers

PMID: 8601626
DOI: 10.1172/JCI118587
PMCID: PMC507225

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Source receipt: pubmed, retrieved 7 Sept 2026.

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