Article
Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women.
Journal of human genetics - 1 Jan 2003
Omasu Fumihiro, Ezura Yoichi, Kajita Mitsuko, Ishida Ryota, Kodaira Mina, Yoshida Hideo, Suzuki Takao, Hosoi Takayuki, Inoue Satoshi, Shiraki Masataka, Orimo Hajime, Emi Mitsuru
Abstract excerpt
Twin and family studies had shown that genetic factors are important determinants of bone mass. Multiple genes might be involved. One candidate gene, the reversion-induced LIM gene ( RIL), is a PDZ and LIM-domain-containing protein and has been localized within the cytokine cluster of chromosome 5 (5q31.1). In a genetic study of 370 adult Japanese women, we investigated the correlation between radial bone mineral...
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