Article
A deletion polymorphism in the RIZ gene, a female sex steroid hormone receptor coactivator, exhibits decreased response to estrogen in vitro and associates with low bone mineral density in young Swedish women.
The Journal of clinical endocrinology and metabolism - 1 Dec 2004
Grundberg E, Carling T, Brändström H, Huang S, Ribom E L, Ljunggren O, Mallmin H, Kindmark A
Abstract excerpt
Low bone mineral density (BMD) is a major risk factor for osteoporotic fracture, and the trait is under genetic control by a large number of genes. It is recognized that estrogen plays an important role in the maintenance of bone mass by binding to estrogen receptor alpha (ERalpha). RIZ1 has previously been shown to be a specific ERalpha coactivator and strongly enhances its function both in vivo and in vitro. We...
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