Article
Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: a multicenter study.
JAMA - 11 Aug 1999
Mira J P, Cariou A, Grall F, Delclaux C, Losser M R, Heshmati F, Cheval C, Monchi M, Teboul J L, Riché F, Leleu G, Arbibe L, Mignon A, Delpech M, Dhainaut J F
Abstract excerpt
CONTEXT: Tumor necrosis factor alpha (TNF-alpha) is believed to be a cytokine central to pathogenesis of septic shock. TNF2, a polymorphism within the TNF-alpha gene promoter, has been associated with enhanced TNF-alpha production and negative outcome in some severe infections. OBJECTIVES: To investigate the frequency of the TNF2 allele in patients with septic shock and to determine whether the allele is...
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