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Article

Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2003

Arai Takehiro, Kasper Jocelyn S, Skaar Jeffrey R, Ali Syed Hamid, Takahashi Chiaki, DeCaprio James A

Abstract excerpt

Cul1, a member of the cullin ubiquitin ligase family, forms a multiprotein complex known as SCF and plays an essential role in numerous cellular and biological activities. A Cul1 homologue, p185 (Cul7), has been isolated as an simian virus 40 large T antigen-binding protein. To understand the physiological role of p185, we generated mice lacking p185. p185-/- embryos are runted and die immediately after birth...

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Identifiers

PMID: 12904573
DOI: 10.1073/pnas.1733908100
PMCID: PMC187864

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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