Mutational specificity of glyoxal, a product of DNA oxidation, in the lacI gene of wild-type Escherichia coli W3110.

doi:10.1016/s0027-5107(97)00083-3

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Article

Mutational specificity of glyoxal, a product of DNA oxidation, in the lacI gene of wild-type Escherichia coli W3110.

Mutation research - 3 Jul 1997

Murata-Kamiya N, Kamiya H, Kaji H, Kasai H

Abstract excerpt

To determine the mutation spectrum of glyoxal, which is produced from DNA by oxygen free-radicals, we analyzed the chromosomal lacI gene of mutants induced by treatment of a wild-type Escherichia coli strain with glyoxal. The cell death and the mutation frequency increased according to the concen...

Topics

Bacterial Proteins
Base Sequence
Escherichia coli
Escherichia coli Proteins
Gene Frequency
Glyoxal
Lac Repressors
Molecular Sequence Data
Mutagenicity Tests
Mutagens
Mutation
Repressor Proteins
Sequence Deletion

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