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Article

Impact of reactive oxygen species on spontaneous mutagenesis in Escherichia coli.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2006

Sakai Akiko, Nakanishi Mari, Yoshiyama Kaoru, Maki Hisaji

Abstract excerpt

Reactive oxygen species (ROS) are potent oxidants that attack chromosomal DNA and free nucleotides, leading to oxidative DNA damage that causes genetic alterations. To avoid the ROS-mediated mutagenesis, cells have elaborate mechanisms including powerful antioxidant components and repair pathways that eliminate oxidative DNA damage. Because of the effective anti-mutagenic functions, it has been unclear to what...

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PMID: 16824196
DOI: 10.1111/j.1365-2443.2006.00982.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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