Article
The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels.
PLoS genetics - 1 Jan 2012
Pai Athma A, Cain Carolyn E, Mizrahi-Man Orna, De Leon Sherryl, Lewellen Noah, Veyrieras Jean-Baptiste, Degner Jacob F, Gaffney Daniel J, Pickrell Joseph K, Stephens Matthew, Pritchard Jonathan K, Gilad Yoav
Abstract excerpt
Recent gene expression QTL (eQTL) mapping studies have provided considerable insight into the genetic basis for inter-individual regulatory variation. However, a limitation of all eQTL studies to date, which have used measurements of steady-state gene expression levels, is the inability to directly distinguish between variation in transcription and decay rates. To address this gap, we performed a genome-wide...
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