Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel.

doi:10.1007/s004240050253

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Article

Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel.

Pflugers Archiv : European journal of physiology - 1 Jan 2000

Yusaf S P, Wray D, Sivaprasadarao A

Abstract excerpt

Voltage-gated ion channels contain a positively charged transmembrane segment termed S4. Recent evidence suggests that depolarisation of the membrane potential causes this segment to undergo conformational changes that, in turn, lead to the opening of the channel pore. In order to define these co...

Topics

4-Chloromercuribenzenesulfonate
Amino Acid Sequence
Animals
Electrophysiology
Female
Ion Channel Gating
Molecular Sequence Data
Mutation
Oocytes
Patch-Clamp Techniques
Potassium Channels

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