Article
Silencing in yeast rDNA chromatin: reciprocal relationship in gene expression between RNA polymerase I and II.
Molecular cell - 1 Jul 2003
Cioci Francesco, Vu Loan, Eliason Kristilyn, Oakes Melanie, Siddiqi Imran N, Nomura Masayasu
Abstract excerpt
About half of approximately 150 rRNA genes are transcriptionally active in Saccharomyces cerevisiae. Chromatin structures in the inactive, and not the active, copies were previously thought to silence both rRNA genes and reporter Pol II genes. Contrary to this belief, we found that silencing of reporters is much stronger in a mutant with approximately 25 rDNA copies, all of which are transcriptionally active. By...
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