Article
Overexpression of integrin-linked kinase correlates with malignant phenotype in non-small cell lung cancer and promotes lung cancer cell invasion and migration via regulating epithelial-mesenchymal transition (EMT)-related genes.
Acta histochemica - 1 Mar 2013
Chen Donghong, Zhang Yibing, Zhang Xuhua, Li Jing, Han Bing, Liu Shuo, Wang Lingling, Ling Yuan, Mao Shitao, Wang Xiaoge
Abstract excerpt
Integrin-linked kinase (ILK), a member of the serine/threonine kinases, has been implicated in oncogenesis and progression of human cancers. The aim of this study was to characterize the role of ILK in lung cancer aggressiveness and the underlying molecular mechanisms. ILK protein expression was assessed by immunohistochemistry in a cohort of non-small cell lung cancer (NSCLC) patients, and a series of in vitro...
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