Article
Germ-line transcription occurs on both the functional and the non-functional alleles of immunoglobulin constant heavy chain genes.
European journal of immunology - 1 Aug 2003
Delpy Laurent, Le Bert Marc, Cogné Michel, Khamlichi Ahmed Amine
Abstract excerpt
In B cells undergoing class switching, recombination is usually directed to the same switch sequences on both homologous chromosomes and is generally preceded by germ-line transcription initiated from I promoters upstream of immunoglobulin constant heavy chain genes. Whether germ-line transcription occurs on both alleles or is restricted to the productive one has not been directly addressed before. To clearly...
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