Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A reporter gene to analyse the hypermutation of immunoglobulin genes.

Journal of molecular biology - 9 Jun 1995

Chui Y L, Lozano F, Jarvis J M, Pannell R, Milstein C

Abstract excerpt

The affinity maturation of antibodies is driven by somatic hypermutation which is localized to specific segments of the coding genes. The information available on this process derives from studies in vivo. With the intention of developing new approaches, we have constructed a fusion gene between a kappa chain and a selectable neomycin resistance gene, neor. The neor gene, which includes the SV40 small t intron...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Molecular Sequence Data

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 7783211
DOI: 10.1006/jmbi.1995.0318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A reporter gene to analyse the hypermutation of immunoglobulin genes.PMID 7783211Read ↗

Analysis of somatic mutation with a reporter gene construct.Semantic proximity Read ↗

Characterization of the cis-acting elements required for somatic hypermutation of murine antibody V genes using conventional transgenic and transgene homologous recombination approaches.Semantic proximity Read ↗

Detection of gene targeting by co-conversion of a single nucleotide change during replacement recombination at the immunoglobulin mu heavy chain locus.Semantic proximity Read ↗

Evaluation of Foreign Gene Codon Optimization in Yeast: Expression of a Mouse IG Kappa ChainSemantic proximity Read ↗

The mechanism of somatic hypermutation studied with transgenic and transfected target genes.Semantic proximity Read ↗

Mutation in a reporter gene depends on proximity to and transcription of immunoglobulin variable transgenes.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin ĸ light chain genesSemantic proximity Read ↗

Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes.Semantic proximity Read ↗

Rapid methods for the analysis of immunoglobulin gene hypermutation: application to transgenic and gene targeted mice.Semantic proximity Read ↗

Cis‐acting sequences that affect somatic hypermutation of Ig genesSemantic proximity Read ↗

Somatic hypermutation in mouse lambda chains.Semantic proximity Read ↗

Directed molecular evolution by somatic hypermutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.