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Article

S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.

The EMBO journal - 1 Feb 1994

Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt F W

Abstract excerpt

Stimulation of B lymphocytes with a combination of lipopolysaccharide (LPS) and interleukin-4 (IL-4) induces germline transcription of and subsequent switching to the epsilon heavy chain constant region (C epsilon) gene. Mature germline C epsilon transcripts contain a non-coding exon (I epsilon exon) spliced to the C epsilon exons. To distinguish between the potential roles of germline transcription and those of...

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Identifiers

PMID: 8313911
DOI: 10.1002/j.1460-2075.1994.tb06305.x
PMCID: PMC394857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.PMID 8313911Read ↗

Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.Semantic proximity Read ↗

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SεSμ and SεSγ Switch Circles in Human Nasal Mucosa Following Ex Vivo Allergen Challenge: Evidence for Direct as Well as Sequential Class Switch RecombinationSemantic proximity Read ↗

Processing of switch transcripts is required for targeting of antibody class switch recombination.Semantic proximity Read ↗

Differential Regulation of Mouse Germline Ig γ1 and ε Promoters by IL-4 and CD40Semantic proximity Read ↗

Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombination.Semantic proximity Read ↗

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.Semantic proximity Read ↗

Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.Semantic proximity Read ↗

Analysis of the promoter elements necessary for IL-4 and anti-CD40 antibody induction of murine Fc epsilon RII (CD23): comparison with the germline epsilon promoter.Semantic proximity Read ↗

Inefficient processing of mRNA for the membraneform of IgE is a genetic mechanism to limit recruitment of IgE‐secreting cellsSemantic proximity Read ↗

Switch circles from IL-4-directed epsilon class switching from human B lymphocytes. Evidence for direct, sequential, and multiple step sequential switch from mu to epsilon Ig heavy chain gene.Semantic proximity Read ↗

NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.Semantic proximity Read ↗

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