Article
S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.
The EMBO journal - 1 Feb 1994
Bottaro A, Lansford R, Xu L, Zhang J, Rothman P, Alt F W
Abstract excerpt
Stimulation of B lymphocytes with a combination of lipopolysaccharide (LPS) and interleukin-4 (IL-4) induces germline transcription of and subsequent switching to the epsilon heavy chain constant region (C epsilon) gene. Mature germline C epsilon transcripts contain a non-coding exon (I epsilon e...
Topics
- Animals
- B-Lymphocytes
- Base Sequence
- Cell Line
- Cloning, Molecular
- DNA
- Exons
- Gene Expression Regulation
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genes, Switch
- Heterozygote
- Homozygote
- Immunoglobulin E
- Interleukin-4
- Lipopolysaccharides