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Article

Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA.

Nucleic acids research - 15 Jun 2001

Huthoff H, Berkhout B

Abstract excerpt

The HIV-1 untranslated leader RNA can adopt two mutually exclusive conformations that represent alternative secondary structures. This leader RNA can fold either an extended duplex through long-distance base pairing or a branched conformation in which the RNA locally folds into hairpin structures. Both leader RNA conformations have the TAR hairpin in common, which forms the extreme 5' end of all HIV-1...

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Identifiers

PMID: 11410668
DOI: 10.1093/nar/29.12.2594
PMCID: PMC55741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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