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Article

Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging.

Retrovirology - 24 Jul 2012

Das Atze T, Vrolijk Martine M, Harwig Alex, Berkhout Ben

Abstract excerpt

BACKGROUND: The TAR hairpin is present at both the 5' and 3' end of the HIV-1 RNA genome. The 5' element binds the viral Tat protein and is essential for Tat-mediated activation of transcription. We recently observed that complete TAR deletion is allowed in the context of an HIV-1 variant that does not depend on this Tat-TAR axis for transcription. Mutations that open the 5' stem-loop structure did however affect...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22828074
DOI: 10.1186/1742-4690-9-59
PMCID: PMC3432602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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