Dependence of mutational asymmetry on gene-expression levels in the human genome.

Abstract excerpt

A great deal of effort has been devoted to measuring the rates of different types of nucleotide substitutions. Mutation rates are known to depend on factors such as methylation status and nearest-neighbor nucleotide effects. However, until recently, in eukaryotes, the rates have not been considered to be strand specific. In a recent analysis of mammalian lineages, Green et al. (2003) uncovered an asymmetry in the...

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