Article
Ribozymes as therapeutic tools for genetic disease.
Human molecular genetics - 1 Jan 1998
Phylactou L A, Kilpatrick M W, Wood M J
Abstract excerpt
The discovery that RNA can act as a biological catalyst, as well as a genetic molecule, indicated that there was a time when biological reactions were catalysed in the absence of protein-based enzymes. It also provided the platform to develop those catalytic RNA molecules, called ribozymes, as tr...
Topics
- Animals
- Down-Regulation
- Genes, Dominant
- Genetic Diseases, Inborn
- Genetic Therapy
- Humans
- Introns
- Mutation
- Nucleic Acid Conformation
- RNA
- RNA Splicing
- RNA, Catalytic