Article
Rescue of epithelial HCO3- secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del.
The Journal of physiology - 1 Nov 2012
Xiao Fang, Li Junhua, Singh Anurag Kumar, Riederer Brigitte, Wang Jiang, Sultan Ayesha, Park Henry, Lee Min Goo, Lamprecht Georg, Scholte Bob J, De Jonge Hugo R, Seidler Ursula
Abstract excerpt
This study investigated whether expression of the common cystic fibrosis transmembrane conductance regulator (CFTR) mutant F508del in the apical membrane of enterocytes confers increased bicarbonate secretory capacity on the intestinal epithelium of F508del mutant mice compared to that of CFTR knockout (KO) mice. CFTR KO mice, F508del mutant mice (F508del) and wild-type (WT) littermates were bred on the FVB/N...
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