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Article

Guanylate cyclase 2C agonism corrects CFTR mutants.

JCI insight - 5 Oct 2017

Arora Kavisha, Huang Yunjie, Mun Kyushik, Yarlagadda Sunitha, Sundaram Nambirajan, Kessler Marco M, Hannig Gerhard, Kurtz Caroline B, Silos-Santiago Inmaculada, Helmrath Michael, Palermo Joseph J, Clancy John P, Steinbrecher Kris A, Naren Anjaparavanda P

Abstract excerpt

Cystic fibrosis (CF) is a genetic disorder in which epithelium-generated fluid flow from the lung, intestine, and pancreas is impaired due to mutations disrupting CF transmembrane conductance regulator (CFTR) channel function. CF manifestations of the pancreas and lung are present in the vast majority of CF patients, and 15% of CF infants are born with obstructed gut or meconium ileus. However, constipation is a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28978796
DOI: 10.1172/jci.insight.93686
PMCID: PMC5841874

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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