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Article

Mutational landscape of receptor guanylyl cyclase C: Functional analysis and disease-related mutations.

IUBMB life - 1 Jun 2020

Bose Avipsa, Banerjee Sanghita, Visweswariah Sandhya S

Abstract excerpt

Guanylyl cyclase C (GC-C) is the receptor for the heat-stable enterotoxin, which causes diarrhea, and the endogenous ligands, guanylin and uroguanylin. GC-C is predominantly expressed in the intestinal epithelium and regulates fluid and ion secretion in the gut. The receptor has a complex domain organization, and in the absence of structural information, mutational analysis provides clues to mechanisms of...

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Identifiers

PMID: 32293781
DOI: 10.1002/iub.2283
PMCID: PMC7611479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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