Article
Genetic control of non obese diabetic mice susceptibility to high-dose streptozotocin-induced diabetes.
Diabetologia - 1 Sept 2003
Gonzalez C, Cuvellier S, Hue-Beauvais C, Lévi-Strauss M
Abstract excerpt
AIMS/HYPOTHESIS: Streptozotocin is a monofunctional alkylating agent that induces diabetes in a large variety of mammals. While multiple low doses of streptozotocin induce immune-mediated diabetes, a single high dose of streptozotocin causes a strictly toxic diabetes. Among mouse strains, non-obe...
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