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Unexpected sensitivity of nonobese diabetic mice with a disrupted poly(ADP-Ribose) polymerase-1 gene to streptozotocin-induced and spontaneous diabetes.

Diabetes - 1 May 2002

Gonzalez Cristina, Ménissier De Murcia Josiane, Janiak Philip, Bidouard Jean-Pierre, Beauvais Catherine, Karray Saoussen, Garchon Henri-Jean, Lévi-Strauss Matthieu

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that consumes NAD in response to DNA strand breaks. Its excessive activation seems particularly deleterious to pancreatic beta-cells, as exemplified by the complete resistance of PARP-1-deficient mice to the toxic diabetes induced by streptozotocin. Because of the possible implication of this enzyme in type 1 diabetes, many human trials using...

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PMID: 11978644
DOI: 10.2337/diabetes.51.5.1470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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