Article
Congenic mapping and candidate gene analysis for streptozotocin-induced diabetes susceptibility locus on mouse chromosome 11.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2018
Maegawa Tomoki, Miyasaka Yuki, Kobayashi Misato, Babaya Naru, Ikegami Hiroshi, Horio Fumihiko, Takahashi Masahide, Ohno Tamio
Abstract excerpt
Streptozotocin (STZ) has been widely used to induce diabetes in rodents. Strain-dependent variation in susceptibility to STZ has been reported; however, the gene(s) responsible for STZ susceptibility has not been identified. Here, we utilized the A/J-11SM consomic strain and a set of chromosome 11 (Chr. 11) congenic strains developed from A/J-11SM to identify a candidate STZ-induced diabetes susceptibility gene....
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