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Article

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes.

Diabetes - 1 Apr 1999

Flodström M, Tyrberg B, Eizirik D L, Sandler S

Abstract excerpt

Nitric oxide (NO), synthesized by the inducible isoform of nitric oxide synthase (iNOS), has been proposed as a mediator of immune-induced beta-cell destruction in type 1 diabetes. To evaluate the role of iNOS for beta-cell dysfunction and death, we investigated the sensitivity of beta-cells from mice genetically deficient in this enzyme (iNOS-/-, background C57BL/6x129SvEv, H-2b) both to interleukin...

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Identifiers

PMID: 10102685
DOI: 10.2337/diabetes.48.4.706

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