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Article

Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans.

Antimicrobial agents and chemotherapy - 1 Sept 2005

Chau Andrew S, Gurnani Maya, Hawkinson Robyn, Laverdiere Michel, Cacciapuoti Anthony, McNicholas Paul M

Abstract excerpt

Two clinical Candida albicans isolates that exhibited high-level resistance to azoles and modest decreases in susceptibility to amphotericin B were cultured from unrelated patients. Both isolates harbored homozygous nonsense mutations in ERG3, which encodes an enzyme, sterol Delta5,6-desaturase, involved in ergosterol synthesis. Extraction and analysis of the sterols from both isolates confirmed the absence of...

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Identifiers

PMID: 16127034
DOI: 10.1128/AAC.49.9.3646-3651.2005
PMCID: PMC1195422

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of sterol Delta5,6-desaturase attenuates virulence in Candida albicans.PMID 16127034Read ↗

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