Article
Distinct mechanisms mediate the initial and sustained phases of integrin-mediated activation of the Raf/MEK/mitogen-activated protein kinase cascade.
The Journal of biological chemistry - 16 Oct 1998
Howe A K, Juliano R L
Abstract excerpt
Integrin-mediated adhesion to the extracellular matrix activates the canonical mitogen-activated protein kinase cascade, although the exact mechanism is not fully resolved. We show that integrin-mediated activation of Raf-1, an upstream regulator of mitogen-activated protein kinase, occurs in two...
Topics
- 3T3 Cells
- Actins
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Adhesion
- Cytoskeleton
- Enzyme Activation
- Integrins
- MAP Kinase Kinase 1
- Mice
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Protein Binding
- Protein Kinase C
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins c-raf
- Signal Transduction