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Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.

Genes, chromosomes & cancer - 1 May 2002

Langabeer Stephen E, Gale Rosemary E, Rollinson Sara J, Morgan Gareth J, Linch David C

Abstract excerpt

The AML1 gene encodes a transcription factor that, together with its heterodimeric partner CBFB, regulates a number of target genes that are essential for normal hemopoiesis. In acute myeloid leukemia (AML), AML1 is disrupted not only by chromosomal translocations but also by mutations in the runt domain, which binds both DNA and CBFB. Acquired mutations have been described predominantly in the AML FAB type M0....

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Share to Core Binding Factor Alpha 2 Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Megakaryoblastic, Acute

Share to Leukemia, Myeloid, Acute

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Source

Identifiers

PMID: 11921279
DOI: 10.1002/gcc.10031

Genes

CBFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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