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Article

Mutational analysis of loxP sites for efficient Cre-mediated insertion into genomic DNA.

Genesis (New York, N.Y. : 2000) - 1 Jul 2003

Thomson James G, Rucker Edmund B, Piedrahita Jorge A

Abstract excerpt

The Cre/loxP system has been used in transgenic models primarily to excise DNA flanked by loxP sites for gene deletion. However, the insertion reaction is more difficult to control since the excision event is kinetically favored. Mutant loxP sites favoring integration were identified using a nove...

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Identifiers

PMID: 12872248
DOI: 10.1002/gene.10211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12872248-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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