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Article

Bcl-2 activates a programme of premature senescence in human carcinoma cells.

The Biochemical journal - 15 Oct 2003

Crescenzi Elvira, Palumbo Giuseppe, Brady Hugh J M

Abstract excerpt

The apoptosis regulator Bcl-2 has been shown to modulate cell-cycle progression, favouring a quiescent state over a proliferative state, in both normal and tumour cells. We show here that constitutive expression of Bcl-2 in human carcinoma cells results in a cell-cycle arrest that within a few days can become irreversible. Arrested cells acquire a senescent-like phenotype, which consists of several characteristic...

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Source

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Identifiers

PMID: 12871207
DOI: 10.1042/BJ20030868
PMCID: PMC1223693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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