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Article

Paradoxical role of apoptosis in tumor progression

7 Nov 2002

Abstract excerpt

Tumors frequently acquire resistance to apoptosis that is expected to contribute to malignant phenotype and reduce sensitivity to treatment. In fact, inactivation of p53 tumor suppressor gene resulting in suppression of apoptosis serves as a negative prognostic marker. Surprisingly, expression of a strong anti-apoptotic protein Bcl-2, another mechanism to avoid apoptosis, was found to be associated with a...

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PMID: 12461782
DOI: 10.1002/jcb.10382

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