Article
Bcl-2 promotes premature senescence induced by oncogenic Ras.
Biochemical and biophysical research communications - 11 Apr 2003
Tombor Bálint, Rundell Kathleen, Oltvai Zoltán N
Abstract excerpt
The expression of the apoptosis inhibitory protein, Bcl-2, is increased in naturally senescing human fibroblasts and upon induction of their senescence-like growth arrest by oxidative stress, implying its role in maintaining their extended viability. Oncogenic Ras(V12) protein induces signaling cascades that result in the premature senescence of primary fibroblast cells, which are insensitive to...
Topics
- Apoptosis
- Cell Cycle
- Cell Line
- Cell Transformation, Neoplastic
- Cellular Senescence
- Fibroblasts
- Genes, bcl-2
- Humans
- Oxidative Stress
- Phenotype
- Proto-Oncogene Proteins c-bcl-2