Article
The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry.
The EMBO journal - 1 Aug 1997
Huang D C, O'Reilly L A, Strasser A, Cory S
Abstract excerpt
The Bcl-2 family of proteins regulate apoptosis, some antagonizing cell death and others facilitating it. It has recently been demonstrated that Bcl-2 not only inhibits apoptosis but also restrains cell cycle entry. We show here that these two functions can be genetically dissociated. Mutation of...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Apoptosis
- Cell Cycle
- Cell Line
- Conserved Sequence
- Genes, Dominant
- Genes, bcl-2
- Genes, p53
- Humans
- Mice
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Proto-Oncogene Proteins c-bcl-2
- Rats
- Transfection