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Article

Initiation of premature senescence by Bcl-2 in hypoxic condition.

International journal of clinical and experimental pathology - 1 Jan 2014

Wang Wei, Wang Desheng, Li Hong

Abstract excerpt

Senescence, a state of cell cycle arrest, has been regarded as an intrinsic barrier to malignance. Although being repressed in most immortal tumors, the genetic program of senescence can be reactivated by critical regulators, including the apoptosis regulator Bcl-2. We showed here that hypoxic condition resulted in an irreversible senescence-like phenotype with increased expression of Bcl-2 in mouse melanoma B16...

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Identifiers

PMID: 24966955
PMCID: PMC4069934

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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