Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

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Article

Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved.

Cancer research - 1 Jun 1995

Wang E

Abstract excerpt

Programmed cell death (apoptosis) is an active process by which cells initiate their own self-destruction. Growing evidence shows that this event is controlled by the activation of unique gene expression; some function as survival genes, such as bcl2, and others as killer genes, such as ced3 or interleukin converting enzyme. Likewise, external factors, such as the presence or absence of stimuli in the...

Topics

3T3 Cells
Animals
Apoptosis
Cell Count
Cell Death
Cell Survival
Cells, Cultured
Cellular Senescence
Culture Media, Serum-Free
DNA
Down-Regulation
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation

Humans

Mice

Microscopy, Fluorescence

Phenotype

Proto-Oncogene Proteins

Source

Open in PubMed

Identifiers

PMID: 7757977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7757977-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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