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Article

Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence.

Journal of virology - 1 Dec 2002

Noris Emanuela, Zannetti Claudia, Demurtas Anna, Sinclair John, De Andrea Marco, Gariglio Marisa, Landolfo Santo

Abstract excerpt

Primary human embryo lung fibroblasts and adult diploid fibroblasts infected by the human cytomegalovirus (HCMV) display beta-galactosidase (beta-Gal) activity at neutral pH (senescence-associated beta-Gal [SA-beta-Gal] activity) and overexpression of the plasminogen activator inhibitor type 1 (PAI-1) gene, two widely recognized markers of the process designated premature cell senescence. This activity is higher...

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Source

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Identifiers

PMID: 12414954
DOI: 10.1128/jvi.76.23.12135-12148.2002
PMCID: PMC136868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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