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Article

Survivin and escaping in therapy‐induced cellular senescence

27 May 2010

Abstract excerpt

Therapy-induced accelerated cellular senescence (ACS) is a reversible tumor response to chemotherapy that is likely detrimental to the overall therapeutic efficacy of cancer treatment. To further understand the mechanism by which cancer cells can escape the sustained cell cycle arrest in ACS, we established a tissue culture model, in which the p53-null NCI-H1299 cells can be induced into senescence by an...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Telomeres, Telomerase, and Senescence

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PMID: 20503268
DOI: 10.1002/ijc.25482

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