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Article

Drosophila Rheb GTPase is required for cell cycle progression and cell growth.

Journal of cell science - 1 Sept 2003

Patel Parthive H, Thapar Nitika, Guo Lea, Martinez Monica, Maris John, Gau Chia-Ling, Lengyel Judith A, Tamanoi Fuyuhiko

Abstract excerpt

Precise body and organ sizes in the adult animal are ensured by a range of signaling pathways. In a screen to identify genes affecting hindgut morphogenesis in Drosophila, we identified a P-element insertion in dRheb, a novel, highly conserved member of the Ras superfamily of G-proteins. Overexpression of dRheb in the developing fly (using the GAL4:UAS system) causes dramatic overgrowth of multiple tissues: in...

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PMID: 12893813
DOI: 10.1242/jcs.00661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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