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Article

Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.

Molecular and cellular biology - 1 Feb 2014

Young Evelin, Zheng Ze-Yi, Wilkins Angela D, Jeong Hee-Tae, Li Min, Lichtarge Olivier, Chang Eric C

Abstract excerpt

Ras can act on the plasma membrane (PM) to mediate extracellular signaling and tumorigenesis. To identify key components controlling Ras PM localization, we performed an unbiased screen to seek Schizosaccharomyces pombe mutants with reduced PM Ras. Five mutants were found with mutations affecting the same gene, S. pombe erf2 (sp-erf2), encoding sp-Erf2, a palmitoyltransferase, with various activities. sp-Erf2...

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Identifiers

PMID: 24248599
DOI: 10.1128/MCB.01248-13
PMCID: PMC3911504

Genes

ZDHHC9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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