Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle.

Endocrinology - 1 Aug 2021

Zhou Jin, Gauthier Karine, Ho Jia Pei, Lim Andrea, Zhu Xu-Guang, Han Cho Rong, Sinha Rohit Anthony, Cheng Sheue-Yann, Yen Paul Michael

Abstract excerpt

Skeletal muscle (SM) weakness occurs in hypothyroidism and resistance to thyroid hormone α (RTHα) syndrome. However, the cell signaling and molecular mechanism(s) underlying muscle weakness under these conditions is not well understood. We thus examined the role of thyroid hormone receptor α (TRα), the predominant TR isoform in SM, on autophagy, mitochondrial biogenesis, and metabolism to demonstrate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Energy Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothyroidism

Share to Lipid Metabolism

Share to Muscle, Skeletal

Share to Mutation

Share to Thyroid Hormone Receptors alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 34086893
DOI: 10.1210/endocr/bqab112
PMCID: PMC8427735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thyroid Hormone Receptor α Regulates Autophagy, Mitochondrial Biogenesis, and Fatty Acid Use in Skeletal Muscle.PMID 34086893Read ↗

Lipid mediated ER-stress contributes to the pathogenesis of mitochondrial myopathiesSemantic proximity Read ↗

RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR.Semantic proximity Read ↗

The paradoxical lean phenotype of hypothyroid mice is marked by increased adaptive thermogenesis in the skeletal muscle.Semantic proximity Read ↗

Rac1 deficiency reduces mitochondrial respiratory capacity, impairs fatty acid metabolism and causes muscle wastingSemantic proximity Read ↗

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset MyopathySemantic proximity Read ↗

Lipin1 deficiency causes sarcoplasmic reticulum stress and chaperone‐responsive myopathySemantic proximity Read ↗

Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscleSemantic proximity Read ↗

Resveratrol Blunts Mitochondrial Loss in Slow and Mixed Skeletal Muscle Phenotypes of Non-Human Primates following a Long-Term High Fat/Sugar Diet.Semantic proximity Read ↗

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21.Semantic proximity Read ↗

Thyroid hormone action in metabolic regulationSemantic proximity Read ↗

Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLDSemantic proximity Read ↗

Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass declineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.