Recent advances in understanding lipodystrophy: a focus on lipodystrophy-associated cardiovascular disease and potential effects of leptin therapy on cardiovascular function

Abstract excerpt

Lipodystrophy is a disease characterized by a partial or total absence of adipose tissue leading to severe metabolic derangements including marked insulin resistance, type 2 diabetes, hypertriglyceridemia, and steatohepatitis. Lipodystrophy is also a source of major cardiovascular disorders which, in addition to hepatic failure and infection, contribute to a significant reduction in life expectancy. Metreleptin, t...

Topics

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• Gene Regulatory Networks
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Lipodystrophy
• Metabolic Syndrome
• Mutation
• Nuclear Structure and Function
• Phenotype

Identifiers and source

Literature Corpus work

53c4791a-a750-5f47-8392-5bf34469449c

DOI

10.12688/f1000research.20150.1