Article
The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G.
Proceedings of the National Academy of Sciences of the United States of America - 8 Nov 2005
Yamamoto Yasufumi, Singh Chingakham Ranjit, Marintchev Assen, Hall Nathan S, Hannig Ernest M, Wagner Gerhard, Asano Katsura
Abstract excerpt
Eukaryotic translation initiation factor (eIF) 5 is crucial for the assembly of the eukaryotic preinitiation complex. This activity is mediated by the ability of its C-terminal HEAT domain to interact with eIF1, eIF2, and eIF3 in the multifactor complex and with eIF4G in the 48S complex. However, the binding sites for these factors on eIF5-C-terminal domain (CTD) have not been known. Here we present a homology...
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