Article
Novel role of Y1 receptors in the coordinated regulation of bone and energy homeostasis.
The Journal of biological chemistry - 29 Jun 2007
Baldock Paul A, Allison Susan J, Lundberg Pernilla, Lee Nicola J, Slack Katy, Lin En-Ju D, Enriquez Ronaldo F, McDonald Michelle M, Zhang Lei, During Matthew J, Little David G, Eisman John A, Gardiner Edith M, Yulyaningsih Ernie, Lin Shu, Sainsbury Amanda, Herzog Herbert
Abstract excerpt
The importance of neuropeptide Y (NPY) and Y2 receptors in the regulation of bone and energy homeostasis has recently been demonstrated. However, the contributions of the other Y receptors are less clear. Here we show that Y1 receptors are expressed on osteoblastic cells. Moreover, bone and adipose tissue mass are elevated in Y1(-/-) mice with a generalized increase in bone formation on cortical and cancellous...
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