Article
Neuropeptide Y is a critical modulator of leptin's regulation of cortical bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2013
Wong Iris P L, Nguyen Amy D, Khor Ee Cheng, Enriquez Ronaldo F, Eisman John A, Sainsbury Amanda, Herzog Herbert, Baldock Paul A
Abstract excerpt
Leptin signaling is required for normal bone homeostasis; however, loss of leptin results in differing effects on cortical and cancellous bone, as well as altered responses between the axial and appendicular regions. Local β-adrenergic actions are responsible for the greater cancellous bone volume in leptin-deficient (ob/ob) mice; however, the mechanism responsible for the opposing reduction in cortical bone in...
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