Article
Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin.
Molecular and cellular biology - 1 Apr 2004
Hohmann J G, Teklemichael D N, Weinshenker D, Wynick D, Clifton D K, Steiner R A
Abstract excerpt
Neuropeptide Y (NPY) and galanin have both been implicated in the regulation of body weight, yet mice bearing deletions of either of these molecules have unremarkable metabolic phenotypes. To investigate whether galanin and NPY might compensate for one another, we produced mutants lacking both neuropeptides (GAL(-/-)/NPY(-/-)). We found that male GAL(-/-)/NPY(-/-) mice ate significantly more and were much heavier...
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