Article
Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to body weight.
PloS one - 22 Dec 2009
Baldock Paul A, Lee Nicola J, Driessler Frank, Lin Shu, Allison Susan, Stehrer Bernhard, Lin En-Ju D, Zhang Lei, Enriquez Ronald F, Wong Iris P L, McDonald Michelle M, During Matthew, Pierroz Dominique D, Slack Katy, Shi Yan C, Yulyaningsih Ernie, Aljanova Aygul, Little David G, Ferrari Serge L, Sainsbury Amanda, Eisman John A, Herzog Herbert
Abstract excerpt
Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central perception of energy status. Mice lacking neuropeptide Y (NPY), a well-known orexigenic factor whose hypothalamic expression is increased in fasting, have significantly increased bone mass in...
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