Article
Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A.
The Journal of biological chemistry - 25 Dec 1998
Mateer S C, Fedorov S A, Mumby M C
Abstract excerpt
SV40 small tumor antigen (small-t) was used as a model to identify structural elements involved in the interactions between regulatory proteins and protein phosphatase 2A (PP2A). Using mutant proteins and synthetic peptides, we identified a small domain within small-t that is a major site for int...
Topics
- Amino Acid Sequence
- Antigens, Polyomavirus Transforming
- Binding Sites
- Circular Dichroism
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phosphoprotein Phosphatases
- Protein Binding
- Protein Conformation
- Protein Phosphatase 2
- Sequence Homology, Amino Acid
- Simian virus 40
- Zinc