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Article

Biological activities of staphylococcal enterotoxin type A mutants with N-terminal substitutions.

Infection and immunity - 1 Jun 1995

Harris T O, Betley M J

Abstract excerpt

The purpose of this study was to examine the importance of certain N-terminal amino acid residues of staphylococcal enterotoxin type A (SEA) for biological activity. The results confirm our previous observation that Asn-25, Phe-47, and Leu-48 are important for SEA's emetic and superantigen activities. Substitutions at six other sites (Leu-12, Lys-14, Ser-16, Asp-45, Gln-46, and Thr-51) did not reveal any...

Topics

Animals
Base Sequence
Enterotoxins
Female
Histocompatibility Antigens Class II
Lymphocyte Activation
Macaca mulatta
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
Staphylococcus aureus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Superantigens

Vomiting

Source

Open in PubMed Open full text

Identifiers

PMID: 7768592
DOI: 10.1128/iai.63.6.2133-2140.1995
PMCID: PMC173277

Genes

SEA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7768592-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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