Article
Concomitant loss of conformation and superantigenic activity of staphylococcal enterotoxin B deletion mutant proteins.
Infection and immunity - 1 Jun 1993
Metzroth B, Marx T, Linnig M, Fleischer B
Abstract excerpt
The T-cell-stimulating activity of staphylococcal enterotoxin B (SEB) is an important factor in the pathogenesis of certain staphylococcal diseases. To investigate the immunologically active domains of the SEB molecule, we have produced truncated fragments of recombinant SEB by C-terminal and N-t...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Bacterial
- Base Sequence
- DNA, Bacterial
- Enterotoxins
- Gene Deletion
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutation
- Recombinant Fusion Proteins
- Staphylococcus aureus
- Structure-Activity Relationship