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Article

Concomitant loss of conformation and superantigenic activity of staphylococcal enterotoxin B deletion mutant proteins.

Infection and immunity - 1 Jun 1993

Metzroth B, Marx T, Linnig M, Fleischer B

Abstract excerpt

The T-cell-stimulating activity of staphylococcal enterotoxin B (SEB) is an important factor in the pathogenesis of certain staphylococcal diseases. To investigate the immunologically active domains of the SEB molecule, we have produced truncated fragments of recombinant SEB by C-terminal and N-terminal deletions. The fragments were expressed as fusion proteins with protein A, including a cleavage site to remove...

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Identifiers

PMID: 8500880
DOI: 10.1128/iai.61.6.2445-2452.1993
PMCID: PMC280867

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