Article
Mutations can cause large changes in the conformation of a denatured protein.
Biochemistry - 5 Oct 1993
Flanagan J M, Kataoka M, Fujisawa T, Engelman D M
Abstract excerpt
Deletion of 13 amino acids from the carboxyl terminus of staphylococcal nuclease (WTSNase delta) results in a denatured, partially unfolded molecule that lacks significant persistent secondary structure but is relatively compact and monomeric under physiological conditions [Shortle & Meeker (1989) Biochemistry 28, 936-944; Flanagan et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 748-752]. Because of these and...
Topics
- Algorithms
- Circular Dichroism
- Hot Temperature
- Hydrogen-Ion Concentration
- Mathematics
- Micrococcal Nuclease
- Mutation
- Peptide Fragments
- Protein Conformation
- Protein Denaturation
- Protein Structure, Secondary
- Scattering, Radiation
- Solvents
- X-Rays